European Cytokine Network
MENUInterleukin-12 induced interferon-g increases inflammation in acute dextran sulfate sodium induced colitis in mice. Volume 11, numéro 1, March 2000
Illustrations
Department of Internal Medicine I, University of Regensburg, D-93042 Regensburg, Germany. werner.falk@klinik.uni-regensburg.de
- Mots-clés : inflammatory bowel disease, intestinal inflammation, neutralization, IL-12.
- Page(s) : 67-74
- Année de parution : 2000
INTRODUCTION The pathogenesis of inflammatory bowel disease (IBD) is still unknown. There is increasing evidence that Th1 cells and their cytokines are implicated in intestinal inflammation. Expression of IFN-gamma has been reported in peripheral blood mononuclear cells and in cells isolated from colon biopsies of patients with IBD [1-7]. In patients with Crohn's disease (CD) greater numbers of IL-2- and IFN-gamma-secreting T cells were [...]