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European Cytokine Network

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Interleukin-12 induced interferon-g increases inflammation in acute dextran sulfate sodium induced colitis in mice. Volume 11, numéro 1, March 2000

Auteurs
Department of Internal Medicine I, University of Regensburg, D-93042 Regensburg, Germany. werner.falk@klinik.uni-regensburg.de

INTRODUCTION The pathogenesis of inflammatory bowel disease (IBD) is still unknown. There is increasing evidence that Th1 cells and their cytokines are implicated in intestinal inflammation. Expression of IFN-gamma has been reported in peripheral blood mononuclear cells and in cells isolated from colon biopsies of patients with IBD [1-7]. In patients with Crohn's disease (CD) greater numbers of IL-2- and IFN-gamma-secreting T cells were [...]