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Fibronectin increases the migration induced by stromal derived factor-1a (SDF-1a) in pre-B acute lymphoblastic leukemia cells. Volume 12, numéro 2, June 2001

Auteurs
Groupe MERCI, Faculté de Médecine-Pharmacie, 22, boulevard Gambetta, 76183 Rouen Cedex, France.
  • Page(s) : 223-30
  • Année de parution : 2001

INTRODUCTION Acute lymphoblastic leukemia (ALL) is usually a result of malignant transformation of B-lymphoid precursors in bone marrow [1, 2]. Leukemic cells usually egress from the bone marrow microenvironment and circulate in the peripheral blood. Mohle et al. demonstrated that this phenomenon depends in part on the chemotactic response to a chemokine, the stromal cell-derived factor (SDF-1alpha) [3]. SDF-1alpha is a member of the CXC [...]