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The CD14-260 C => T promoter polymorphism co-segregates with the tumor necrosis factor-alpha (TNF-alpha)-308 G => A polymorphism and is associated with the interleukin-1beta (IL-1beta) synthesis capacity of human leukocytes Volume 13, numéro 2, June 2002

Auteurs
Department of Anesthesia, Academic Medical Center, University of Amsterdam, Meibergdreef 9, 1100 DD Amsterdam, The Netherlands.
  • Page(s) : 230-3
  • Année de parution : 2002

INTRODUCTION A major trigger for the release of cytokines is the binding of lipopolysaccharide (LPS) to the monocyte surface receptor CD14. Consequently, monocytes produce and release cytokines such as tumor necrosis factor-alpha (TNF-alpha) and IL-1beta. Recent research on the interindividual variance in cytokine release elucidated the role of genetic polymorphisms [1]. The genes for CD14 [2] and TNF-alpha [3] carry polymorphisms within [...]