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European Cytokine Network

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Cytokine pattern in cystic fibrosis patients during antibiotic therapy and gene therapy using adenoviral vector Volume 13, numéro 3, September 2002

Auteurs
Service de Pédiatrie, Pneumologie, Allergologie, Mucoviscidose, Hôpital Debrousse, 29, rue Sœur Bouvier, 69322 Lyon Cedex 05. France.
  • Page(s) : 324-30
  • Année de parution : 2002

INTRODUCTION Cystic fibrosis (CF) is the most common recessive genetic disease in Caucasian, and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene [1]. The disease is associated with a progressive decline in lung function, with more than 90% of deaths attributable to pulmonary manifestations [2]. Since 1993, gene therapy for CF has been developed in order to transfer a normal CFTR gene copy into [...]