JLE

European Cytokine Network

MENU

Infection of mice with Mycobacterium bovis-BCG induces both Th1 and Th2 immune responses in the absence of interferon-gamma signalling. Volume 10, numéro 2, June 1999

Auteurs
Zentrum für Infektionsforschung, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
  • Page(s) : 147-54
  • Année de parution : 1999

INTRODUCTION Mycobacterial infections normally induce a profound Th1 type DTH response characterized by the selective infiltration and activation of macrophages and T cells at sites where the mycobacteria are present. The key elements of the mycobacteria-induced cellular responses are the T cell-dependent production of interferon-gamma (IFN-gamma), and the macrophage-dependent production of tumour necrosis factor-alpha (TNF-alpha) [...]