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 Printable version |
Activation of caspases by death receptors. |
European Cytokine Network. Volume 9, Number 4, 681-4, December 1998, Conférence : Cytokines and apoptosis in the cardiovascular system Halle (Germany) 26-27 February 1998
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 Free Article
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Author(s) : H. Bantel, T. Brüning and K. Schulze-Osthoff |
Summary : Caspases form a family of cysteine proteases which are implicated in multiple forms of apoptosis. Their role has been intensively studied during apoptosis triggered by death receptors, but their exact biological functions and mechanisms of activation remain unclear. Here, we summarize the knowledge about the signal transduction pathways of death receptors leading to the activation of caspases as the key effector components of apoptotic cell death. |
Keywords : apoptosis, CD95 (APO-1/Fas), death receptor, tumor necrosis factor, TRAIL. |
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