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Cardiodepression by tumor necrosis factor-alpha. Volume 9, numéro 4, December 1998

Auteurs
Chair of Cardiac Intensive Care at the Department of Medicine III, Martin-Luther University Halle-Wittenberg, Ernst-Grube-Straße 40, D-06097 Halle, Germany. Tel: (+49) 345 557 4545, Fax: (+49) 345 557 4546, e-mail: ursula.mueller-werdan@medizin.uni-halle.de
  • Page(s) : 689-92
  • Année de parution : 1999

TUMOR NECROSIS FACTOR-alpha IS CARDIODEPRESSANT IN VIVO A body of evidence has accumulated in recent years proving that TNF-alpha is cardiodepressant in vivo [1]. Bolus application of TNF-alpha in dogs reversibly provoked a pathologically reduced ventricular ejection fraction, which is a measure of cardiac performance [2]. The cardiovascular alterations of these animals resembled the hemodynamic pattern encountered [...]