JLE

European Cytokine Network

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Myocardial apoptosis in the overloaded and the aging heart: a critical role of mitochondria? Volume 9, numéro 4, December 1998

Auteur
Jürgen Holtz, Institute of Pathophysiology, Martin-Luther-University Halle-Wittenberg, Magdeburger Str. 18, 06097 Halle (Saale), Germany. Tel: (+49) 345 557 1895, Fax: (+49) 345 557 1404.
  • Page(s) : 693-6
  • Année de parution : 1999

INTRODUCTION Myocardial apoptosis is a typical feature of human terminal cardiac failure. However, the quantitative role of the apoptotic process for the progression of failure and the stimuli inducing programmed cell death of cardiomyocytes in the failing heart are unknown. Acute stretch of isolated papillary muscle in vitro induces apoptosis [1], but distension of the extent reported in these in vitro experiments is unlikely [...]