European Cytokine Network
MENUHepatocyte-derived cell lines express a functional receptor for cardiotrophin-1 Volume 8, numéro 3, September 1997
Illustrations
O . Robledo, C. Guillet, S. Chavalier, M. Fourcin, J. Froger, A. Pouplard-Barthelaix, D. Pennica and H. Gascan
- Mots-clés : cardiotrophin-1, gp130, LIF receptor, acute phase proteins, hepatocytes.
- Page(s) : 245-52
- Année de parution : 1997
INTRODUCTION Acute inflammation leads to increased circulating levels of a number of hepatocyte-derived proteins known as acute phase proteins (APP) (reviewed in 1). Interleukin-1 (IL-1) [2], tumor necrosis factor alpha [3] and interleukin-6 (IL-6) [4, 5] are important modulators of APP synthesis in liver cells. IL-6 has been shown to be a major regulatory cytokine for APP synthesis both in vitro and in vivo. Recently, IL-6 [...]