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European Cytokine Network

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Hepatocyte-derived cell lines express a functional receptor for cardiotrophin-1 Volume 8, numéro 3, September 1997

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INTRODUCTION Acute inflammation leads to increased circulating levels of a number of hepatocyte-derived proteins known as acute phase proteins (APP) (reviewed in 1). Interleukin-1 (IL-1) [2], tumor necrosis factor alpha [3] and interleukin-6 (IL-6) [4, 5] are important modulators of APP synthesis in liver cells. IL-6 has been shown to be a major regulatory cytokine for APP synthesis both in vitro and in vivo. Recently, IL-6 [...]