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European Cytokine Network

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Thrombopoietin (Mpl ligand) and the regulation of platelet production Volume 8, numéro 3, September 1997

Auteurs
  • Page(s) : 311-4
  • Année de parution : 1997

Megakaryocytopoiesis is the cellular process of proliferation and differentiation of megakaryocytes leading to the formation of blood platelets. After commitment to the megakaryocytic lineage, megakaryocyte progenitors undergo a number of mitosis (proliferation), then cease cell division but continue to replicate their DNA to produce polyploid cells containing 4 (8N) to 64 (128N) times the usual DNA content (endomitosis). Cessation [...]