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 Printable version |
Invertebrate and fish cytokines. |
European Cytokine Network. Volume 11, Number 3, 354-61, September 2000, Revue
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 Free Article
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Author(s) : Giuseppe Scapigliati, Steve Bird, Christopher J. Secombes |
Summary : Cytokine-like molecules are well described in invertebrates, although most recent studies have revealed that there is analogy, rather than homology, between invertebrate and vertebrate cytokine-like activities. Cytokines certainly appeared early in the evolution of vertebrates, dating back some 400 millions years. Here, evidence will be reviewed and updated of the presence of these molecules in jawed fish and in particular, in bony fish, which represent the oldest group displaying true functionality of immune system as known in modern vertebrates. Many studies during the last ten years have confirmed the presence of functional homologues of mammalian cytokines in fish. In this review, particular attention will be focussed on IL-1b, a very ancient defence cytokine recently sequenced in two species, rainbow trout (Oncorhynchus mykiss) and carp (Cyprinus carpio). Original data on the partial peptide sequence of IL-1b in the mediterranean sea bass Dicentrarchus labrax are also presented. |
Keywords : invertebrates, teleost fish, sea bass, cytokines, IL-1b, evolution. |
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