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Anti-inflammatory response after infusion of p55 soluble tumor necrosis factor receptor fusion protein for severe sepsis Volume 14, numéro 1, March 2003

Auteurs
Division of Surgical Intensive Care, Department of Anesthesiology, Pharmacology and Surgical Intensive Care, Geneva University Hospital, 1211 Geneva 14, Switzerland.
  • Page(s) : 15-9
  • Année de parution : 2003

INTRODUCTION Severe sepsis is associated with a significant degree of morbidity and mortality in intensive care units (ICU) [1, 2]. It can lead to organ failure along with hemodynamic instability, accounting for the potentially fatal outcome of a septic episode [3]. Tumor necrosis factor-alpha(TNF-alpha), interleukin-1 (IL-1) and IL-6 seem to play a key role in the pathogenesis of sepsis. IL-6 is considered [...]