European Cytokine Network
MENUTumor necrosis factor is increased in the spinal cord of an animal model of motor neuron degeneration Volume 9, numéro 2, June 1998
Illustrations
P. Ghezzi, R. Bernardini, R. Giuffrida, M. Bellomo, C. Manzoni, D. Comoletti, E. Di Santo, F. Benigni, T. Mennini
- Mots-clés : TNF, motor neuron disease, spinal cord, mnd mice.
- Page(s) : 139-44
- Année de parution : 1998
INTRODUCTION Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive death of upper and lower motor neurons. The two main pathogenic hypothesis include: autoimmunity and oxidative/excitotoxic damage. The autoimmune hypothesis is supported mainly by the presence of anti-neural and anti-ganglioside antibodies in ALS patients [1] and by the similarities between ALS and an inducible experimental [...]