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European Cytokine Network

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Tumor necrosis factor is increased in the spinal cord of an animal model of motor neuron degeneration Volume 9, numéro 2, June 1998

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INTRODUCTION Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive death of upper and lower motor neurons. The two main pathogenic hypothesis include: autoimmunity and oxidative/excitotoxic damage. The autoimmune hypothesis is supported mainly by the presence of anti-neural and anti-ganglioside antibodies in ALS patients [1] and by the similarities between ALS and an inducible experimental [...]