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Divergent effects of tumor necrosis factor-alpha and lymphotoxin-alpha on lethal endotoxemia and infection with live Salmonella typhimurium in mice Volume 13, numéro 1, March 2002

Auteurs
M.D. Department of Medicine (541), University Medical Center St. Radboud, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands.
  • Page(s) : 104-9
  • Année de parution : 2002

INTRODUCTION Typhoid fever, a systemic disease caused by Salmonella typhi or S. paratyphi, is still one of the major health problems throughout the world, particularly in developing countries. The host defense mechanisms against Salmonella species, an intracellular pathogen, are complex and involve both innate and adaptive immunity. Mononuclear phagocytes play a central role in the control of Salmonella infections, after activation [...]