JLE

European Cytokine Network

MENU

The combination of the interleukin-1alpha (IL-1alpha-889) genotype and the interleukin-10 (IL-10 ATA) haplotype is associated with increased interleukin-10 (IL-10) plasma levels in healthy individuals Volume 13, numéro 1, March 2002

Auteurs
Department of Microbiology and Immunology, University of Tampere Medical School, POB 607, FIN-33 101, Tampere, Finland.
  • Page(s) : 66-71
  • Année de parution : 2002

INTRODUCTION Interleukin-10 is an 18 kDa, homodimeric cytokine which has strong immunosuppressive and anti-inflammatory activities in man. IL-10 has been shown to inhibit proliferation and IL-2 production in activated CD4+ T cells [1], and is also able to induce a long-term antigen-specific anergic state in these cells [2]. The effects of IL-10 on human monocytes include inhibition of lipopolysaccharide-induced production of proinflammatory [...]