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Circulating macrophage colony stimulating factor as a marker of tumour progression Volume 13, numéro 1, March 2002

Auteurs
Médecin-Spécialiste, Institut Curie, 26, rue d'Ulm, 75248 Paris Cedex 05, France.
  • Page(s) : 121-7
  • Année de parution : 2002

INTRODUCTION Colony stimulating factor is a polypeptide growth factor which regulates the survival, proliferation and differentiation of mononuclear phagocytes [1]. Synthesized by many different cell types including fibroblasts, bone marrow stromal cells, lymphocytes and activated macrophages, CSF-1 acts through a high affinity tyrosine kinase receptor encoded by the c-fms proto-oncogene [2], exerting chemotactic effects on precursors of [...]