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 Printable version |
Cytokines in chronic heart failure: possible involvement in the neurohormonal and the cytokine systems at the cAMP level? |
European Cytokine Network. Volume 13, Number 4, 387-8, December 2002, Synthèses
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 Free Article
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Author(s) : Claudia Werner, Harald Loppnow, Mathias Rauchhaus, Armin Wessel, Karl Werdan, Reiner Buchhorn |
Summary : In recent years, the pathophysiological concept of chronic heart failure (CHF) has changed from an isolated hemodynamic view to a more complex concept involving neuroendocrine and inflammatory pathways. New therapeutic strategies, such as b-blocker therapy, are based on these new concepts and provide clinical evidence for a clinical benefit in patients with CHF. The survival benefit of b-blocker therapy in CHF has been related to neurohumoral regulation. Thus, evidence evolved showing that following b-blocker therapy cytokine levels in CHF patients are altered. We have shown that the levels of soluble TNF receptor type 2 correlated well with cAMP in leukocytes. Data from clinical studies in adult and infant CHF patients have demonstrated that b-blocker therapy is accompanied by altered cytokine, cytokine antagonist, and/or soluble cytokine receptor levels. These alterations may result from a dysregulated interaction of b-adrenergic pathways and the cytokine system, and are possibly related to cAMP-dependent regulation of the release or shedding of these mediators. |
Keywords : Adult; b-blocker; children; chronic heart failure; cyclic AMP; cytokine; infant; interleukin; soluble TNF receptor; tumor necrosis factor |
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