Lipid, lipoproteins and atherogenesis profiles in sickle cell disease among Central African patients

Étienne Mokondjimobe; Benjamin Longo-Mbenza; Felix Ovono-Abessolo; Thierry Gombet; Guenole Guie; Edouard Ngou-Milama; Henri Joseph Parra

doi:10.1684/abc.2012.0687



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Lipid, lipoproteins and atherogenesis profiles in sickle cell disease among Central African patients
Annales de Biologie Clinique. Volume 70, Number 2, 183-8, Mars-Avril 2012, Article original
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Author(s) : Étienne Mokondjimobe, Benjamin Longo-Mbenza, Felix Ovono-Abessolo, Thierry Gombet, Guenole Guie, Edouard Ngou-Milama, Henri Joseph Parra
Summary : Lipid and lipopproteins disorders are well established in sera from sickle cell disease (SCD) patients out of Central Africa. The present case-control study was conducted to compare serum levels of total cholesterol (TC), HDL-C, triglycerides (TG), LDL-C and TC/HDL-C ratio (atherogenic index) from SCD homozygotes (SS) in steady state, SCD heterozygotes (AS) and controls (AA) in Brazzaville, Congo. Significant reductions of TC and LDL-C vs. increase in TG were reported in SS. However, significant decrease in HDL-C and increase in atherogenic index were observed in AS. We recommend prevention of oxidative stress, dyslipidemia and atherosclerosis in SCD using hygiene-diet measures. Only longitudinal studies in large populations will provide pathophysiological basis of lipid and lipoproteins disorders in SCD.
Keywords : sickle cell disease, lipids, lipoproteins, atherosclerosis, Central Africa