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 Printable version |
Prevalence of HPV infection in precancerous and cancerous lesions of the uterine cervix in Tunisia |
Annales de Biologie Clinique. Volume 68, Number 3, 297-303, mai-juin 2010, article original
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 Résumé
Article gratuit
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Author(s) : Nahiba Missaoui, Sihem Hmissa, Amel Trabelsi, Mohamed Tahar Yacoubi, Amel Nouira, Lucien Frappart, Moncef Mokni, Sadok Korbi |
Summary : ObjectivesTo investigate the distribution of HPV genotypes inuterine cervical lesions in Central Tunisia in order to predict the impact ofHPV vaccines and HPV-based screening tests among Tunisian women.Material and methodsWe performed a retrospective study of 146 fixed tissues including 30 benign lesions, 36 low-grade cervical intraepithelial neoplasias (CIN1), 45 high-grade cervical intraepithelial neoplasias (CIN2/3), 26 invasive squamous cell carcinomas (SCC) and 9 adenocarcinomas. HPV infection detection and typing were investigated by PCR technique using consensus GP5/GP6 primers and type specific primers for HPV6/11, 16, 18, 31 and 33.ResultsAmong our patients, overall HPV prevalence was 73.6% (p \= 0.0001). HPV infection was associated to 84% of precancerous lesions and 83.9% of cancers. High-risk HPV infection (HPV16 and 18) was detected in 17.4% of CIN1, 74.3% of CIN2/3 (p \= 0.002) and 73.1% of cancers (p \= 0.001). HPV16 was the most common type among CIN2/3 (51.2%, p <\; 0.001), invasive SCC (47.6%, p \= 0.001) and adenocarcinomas (80%, p <\; 0.001).ConclusionThis study supports previous population-based studies in which similar HPV detection rates were found among random samples of women. HPV-based screening tests and HPV vaccination would be efficient in uterine cervix cancer prevention among women in the Central Tunisia. |
Keywords : uterine cervix, cancer, precancerous lesions, HPV, vaccine |
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