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 Printable version |
Prognostic value of S-100B protein plasma measurement after cardiac arrest |
Annales de Biologie Clinique. Volume 68, Number 1, 33-8, janvier-février 2010, article original
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 Résumé
Article gratuit
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Author(s) : S Ziani , N Bertho , G Atlan, M-L Fievet, P Ecollan, J-L Beaudeux |
Summary : S-100B protein is selectively synthesized by glial cells, and is released in biological fluids after acute brain damage. We analyzed initial levels and evolution of plasma S-100B protein concentrations after resuscitated cardiopulmonary arrest (CPA). S-100B levels were determined in 27 subjects at the time of CPA (H0) then 12, 24 and 48 h after resuscitation. Initial levels of S-100B and kinetics revealed that: 1) 95% the of subjects with a concentration of protein S-100B greater than 0.80 μg/L at H0 did not survive\; 2) 62% of subjects with a concentration of protein S-100B lower than 0.80 μg/L at H0 survived\; 3) 100% of subjects with a protein S-100B level lower than 0.80 μg/L at H0 and whose evolution kinetics of S-100B levels showed a decrease survived\; 4) 100% of the subjects whose S-100B levels increased from H12 died. In summary, this study suggests that the threshold of 0.80 μg/L for S-100B plasma levels at H0 could be predictive for the outcome of the CPA, when associated with the kinetic study of S-100B plasma concentration. |
Keywords : S-100B protein, cardiopulmonary arrest, blood measurement, prognostic value |
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