|
|
 |
 |
| |
 Printable version |
Limited predictive value of the IDF definition of metabolic syndrome for the diagnosis of insulin resistance measured with the oral minimal model |
Annales de Biologie Clinique. Volume 67, Number 5, 535-42, septembre-octobre 2009, article original
|
 Résumé
 Free Article
|
Author(s) : E Ghanassia, E Raynaud de Mauverger, J-F Brun, C Fedou, J Mercier |
Summary : Aim: To assess the agreement of the NCEP ATP-III and the IDF definitions of metabolic syndrome and to determine their predictive values for the diagnosis of insulin resistance. Methods: For this purpose, we recruited 150 subjects (94 women and 56 men) and determined the presence of metabolic syndrome using the NCEP-ATP III and IDF definitions. We evaluated their insulin sensitivity S
I using Caumo’s oral minimal model after a standardized hyperglucidic breakfast test. Subjects whose S
I was in the lowest quartile were considered as insulin resistant. We then calculated sensitivity, specificity, positive and negative predictive values of both definitions for the diagnosis of insulin resistance. Results: The prevalence of metabolic syndrome was 37.4% (NCEP-ATP III) and 40% (IDF). Agreement between the two definitions was 96%. Using NCEP-ATP III and IDF criteria for the identification of insulin resistant subjects, sensitivity was 55.3% and 63%, specificity was 68.8% and 67.8%, positive predictive value was 37.5% and 40%, negative predictive value was 81.9% and 84.5%, respectively. Positive predictive value increased with the number of criteria for both definitions. Conclusion: Whatever the definition, the scoring of metabolic syndrome is not a reliable tool for the individual diagnosis of insulin resistance, and is more useful for excluding this diagnosis. |
Keywords : metabolic syndrome, NCEP-ATP III, IDF, insulin resistance, insulin sensitivity minimal model |
|
