Persistent thrombocytopenia in a child: morphological examination of blood platelets established the diagnosis of Wiskott-Aldrich syndrome.

V Latger-Cannard; F Lacroix; J Devignes; S Salignac; D Bensoussan; A Salmon; L Mansuy; P Bordigoni; T Lecompte

doi:10.1684/abc.2008.0197



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Persistent thrombocytopenia in a child: morphological examination of blood platelets established the diagnosis of Wiskott-Aldrich syndrome.
Annales de Biologie Clinique. Volume 66, Number 1, 100-4, Janvier-Février 2008, pratique quotidienne
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Author(s) : V Latger-Cannard, F Lacroix, J Devignes, S Salignac, D Bensoussan, A Salmon, L Mansuy, P Bordigoni, T Lecompte
Summary : Thrombocytopenia frequently occurs in laboratory practice. The present work illustrates, through the presentation of a case report of Wiskott-Aldrich syndrome, the difficulties encountered to identify and characterize thrombocytopenia. The clinicobiological validation of a low platelet count involves both the biologist, who must assume the validation of numeration while mentioning the morphological characteristics of the platelets and other blood cells, as well as the physician who has to interpret these data according to the clinical context.
Keywords : thrombocytopenia, platelet morphology, blood smear, Wiskott-Aldrich syndrome