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 Printable version |
Acquired alpha-thalassemia as early sign for myelodysplastic syndrome (refractory anaemia) with secondary haemochromatosis |
Annales de Biologie Clinique. Volume 65, Number 4, 405-9, Juillet-Août 2007, Pratique quotidienne
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 Résumé
Article gratuit
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Author(s) : J Perrin, A Perrot, V Chenot, J-F Lesesve, A Guerci, M Marchand-Arvier, C Vigneron, T Lecompte |
Summary : We report the case of a 59 year old man presenting a regenerative microcytic hypochromic anaemia. The investigations revealed the presence of haemoglobin H, suggesting abnormalities in the α-globin chains synthesis. Alpha-thalassemia was thus suspected. The patient had no personal or familial history. The association with aniso-poïkilocytosis and a marked iron overload (ferritinemia > 1 500 μg/L) suggested a myelodysplastic syndrome, which was confirmed with a bone marrow aspiration. The pattern was consistent with the Acquired α-Thalassemia-Myelodysplastic Syndrome (ATMDS). About a hundred cases are listed worldwidely and collected in an international registry. The causes of ATMDS are ignored, but recent reports indicate that the ATRX gene may be implicated in the pathogenesis. ATRX is a chromatin-associated protein, involved in the transcription of several genes. The α globin genes could be one of the targets of the ATRX protein. |
Keywords : ATMDS syndrome, haemoglobin H, dyserythropoiesis, acquired alpha-thalassemia, myelodysplasia, secondary haemochromatosis |
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