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Annales de Biologie Clinique. Volume 64, Number 3, 231-5, Mai-Juin 2006, Article original

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Author(s) : AO Touré, D Doupa, S Diop, A Kane, A Kane, MM Ka, T Dieye, D Thiam, L Diakhaté

Summary : Background and aim: antiphospholipids antibodies (APL) are autoantibodies found in lupus erythematosus and disorders like. Their frequency varies between 2 and 62% according to the literature. An increased frequency of cardiac disorders in antiphospholipids (APL) positive lupus has been reported. The aim of our study was to evaluate the role of APL as an independent risk factor of cardiac disorders in patients with systemic lupus erythematosus. Material and method: a prospective study during 14 months has been designed with the cooperation of dermatologic, internal medicine and cardiology departments of the Aristide Le Dantec hospital of Dakar. Platelets count (Beckmann Coulter analyzer), activated partial thromboplastin time (Diagnostiga stago analyzer) and antiphospholipids antibodies (Elisa) were determined. Results: 37 patients affected by lupus were included in this study with a net feminine prevalence (89%)\; 8 (14.6%) had APL’s significant results and 20 presented an echographic heart abnormality. The analysis of our data did not reveal an increased risk of cardiac diseases among APL positive lupic patients as compared to the negative group (p \= 1). Conclusion: the presence of APL in patients with systemic lupus does not so seem to be an independant risk factor of heart diseases.

Keywords : antiphospholipids antibodies, lupus, heart disease