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Annales de Biologie Clinique. Volume 64, Number 2, 177-81, Mars-Avril 2006, Culture-qualité

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Author(s) : S Albarède, A Guyard, E Burg, BN Pham

Summary : In 2003, for the scheme of the French national external quality assessment, Afssaps organized for the first time a survey on auto-antibodies detected on liver, kidney and stomach tissues. This survey had two purposes: first to make an inventory of the methodology applied by the medical laboratories and secondly to assess the quality of the results. The survey sample contained M2 anti-mitochondrial antibodies. Overall results are satisfactory. Concerning the titer of antibodies, a broad dispersion of results was observed (12% of titers were upper than the expected titer). Delivered information to the participants, at the end of the survey, should improve analytical procedures applied by the biologists. An effort of standardization by using titrated internal controls would be suitable.

Keywords : external quality assessment, quality control, auto-antibodies detected on liver, kidney and stomach tissues, M2 anti-mitochondrial antibodies, primary biliary cirrhosis