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Annales de Biologie Clinique. Volume 62, Number 5, 591-4, Septembre-Octobre 2004, pratique quotidienne

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Author(s) : C Caudie , A Schandelong , F Rapoport , C Vial

Summary : We describe a patient who developed overlapping sensory ataxic form of Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) following Campylobacter jejuni infection. Two cerebrospinal fluid examinations shown albuminocytologic dissociation associated with Campylobacter jejuni infection after tongue pierced. He had high titers of monospecific anti-GD1b IgG antibody. Because of the rarety of this disorder the diagnostic was difficult. There is a close association of IgG anti-ganglioside GD1b antibodies in sensory ataxic GBS. The findings of the present study show that antibody to GD1b ganglioside is one of the immunological factors in the pathogenesis of sensory ataxic form of GBS, a rare specific immuno-clinical variant form of GBS with prominent sensory ataxia.

Keywords : Miller Fisher syndrome, Guillain-Barré syndrome, anti-GD1b IgG, autoantibodies to gangliosides, Campylobacter jejuni