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Annales de Biologie Clinique. Volume 62, Number 4, 456-61, Juillet-Août 2004, Pratique quotidienne

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Author(s) : E. Plantin‐Carrenard, F. Cattan, A. Aurengo, B. Dumérat, M.‐J. Foglietti, J.‐L. Beaudeux

Summary : Iodine is an essential element for thyroid hormone synthesis. Iodine disorders induced biological and\\to clinical expression of thyroid dysfunction. Inappropriate iodine intake (by default or by excess) is worrying in terms of public health in France regarding the iodine deficiency and the frequency of iatrogen iodine overloads. Urinary iodine determination which generally implicates the use of a cerimetric method, is an useful tool to evaluate iodine intakes. In this study, we described the analytical aspects of a semiquantitative method of urinary iodine using a redox indicator, ferroin. This method allows the screening of iodine excess or deficiency in a short time (<\; 3 hours) with a good specificity and sensitivity. Since this assay does not require specific apparatus, it could be easily developed in clinical chemistry laboratories for the detection of inappropriate iodine intakes, and could be useful for prevention programs of iodine deficiency.

Keywords : iodine, iodine induced disorder, semiquantitative method, ferroin