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Annales de Biologie Clinique. Volume 61, Number 4, 454-7, Juillet 2003, Pratique quotidienne

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Author(s) : A.Vincenot-Blouin, O.Timbely, W.Abarah-Atassi, H.Mossafa, C.Allard, F.Michel, E.André-Kerneïs

Summary : We reported here a case of persistent polyclonal B-cell lymphocytosis (PPBL) in a 31-year-old female patient. Peripheral blood smears showed atypical binucleated lymphocytes which were polyclonal B-cells with kappa and lambda expression, and without clonal rearrangement of immunoglobulin heavy chain. Cytogenetic analysis found a trisomy 8, with premature chromosome condensation. Clinically, PPBL is associated with moderated splenomegaly, adenopathy, and smoking. It remains to be established whether PPBL is a real pathology or a simple cytological abnormality.

Keywords : lymphocytosis, binucleated lymphocyte