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Recommended algorithms of prescription : diagnosis of iron deficiency and overload


Annales de Biologie Clinique. Volume 59, Number 2, 149-55, Mars - Avril 2001, Revues générales


Résumé   Summary  

Author(s) : M. Vernet, J. Corberand, V. David, Y. Deugnier, J. Frey, P. Giraudet, J.-C. Renversez, G. Sebahoun, 32 bis, rue Chazière, Diamant, 69004 Lyon.

Summary : In view of the recent development of new tests of biochemistry and molecular biology the assessment of iron status should be reconsidered and updated. The French Society of Clinical Biology (SFBC) and the French Society of Hematology (Cellular Hematology Group) recommend algorithms in the diagnosis of iron deficiency and iron overload bearing in mind the best efficiency and health economy. These recommandations are based on the known sensibility and specificity of each test. The analytical requirements for the determination of the tests as well as the clinical and biological signs evoking an iron deficiency or overload are recalled.

Keywords : Iron deficiency - Iron overload - Prescription algorithm.

Pictures


   
  

Figure 1. Arbre décisionnel devant une suspicion de déficit en fer. TGMH : teneur globulaire moyenne en hémoglobine ; VGM : volume globulaire moyen ; Rs-Tf : récepteur soluble de la transferrine ; CRP : protéine C réactive ; Hb : hémoglobine.

* La CRP est prescrite en cas de doute sur l'existence d'un syndrome inflammatoire associé.




   
   Figure 2. Arbre décisionnel devant une suspicion de surcharge en fer. NFS : numération formule sanguine ; ALAT : alanine-amino-transférase ; ASAT : aspartate-amino-transférase ; CRP : protéine C réactive ; CST : coefficient de saturation de la transferrine.



   
    



   
    





 

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