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 Printable version |
Strategies for the search of secretases in Alzheimer’s disease |
Annales de Biologie Clinique. Volume 56, Number 3, 277-84, Mai-Juin 1998, Revues générales
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 Résumé
Article gratuit
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Author(s) : P. Marambaud, N. Chevallier, E. Lopez-Perez, C. Drouot, J. Vizzanova, P. Fulcrand, J. Martinez, S. Wilk, F. Checler |
Summary : In Alzheimer’s disease, cortical areas of affected patients are invaded by extracellular proteinous deposits called senile plaques, the main component of which is called amyloid -peptide or A . This peptide derives from the proteolytic attack of a precursor, the -amyloid precursor protein, by two enzymes called - and -secretases. Alternatively, APP can be cleaved by an additional activity named -secretase that occurs inside the A sequence, the-reby precluding its formation, and concomitantly liberating a secreted fragment, namely APP. Therefore, secretases seem to play a key role in the control of physiological and potentially pathogenic APP catabolites and could be envisioned as possible therapeutic targets in Alzheimer’s disease. Here, we describe possible experimental approaches to identify such proteolytic activities. |
Keywords : Alzheimer’s disease – Secretases – amyloid. |
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