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Serum protein immunofixation in malignant hemopathies other than multiple myeloma and waldenstrom's macroglobulinemia |
Annales de Biologie Clinique. Volume 60, Number 5, 565-70, Septembre - Octobre 2002, Articles originaux
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 Résumé
Article gratuit
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Author(s) : L. Ramont, P.T. Ngoc, B. Pignon, F.-X. Maquart |
Summary : The interest of serum protein immunofixation in myeloma and Waldenström’s macroglobulinemia is widely known. It is not so well defined in other malignant hemopathies. The purpose of this study was to determine immunofixation abnormalities in malignant hemopathies other than multiple myeloma and Waldenström’s macroglobulinemia. We selected serum immunofixations of 61 patients affected by malignant hemopathies and 53 patients affected by other pathologies susceptible to give immunofixation’s alterations. We showed that the frequency of immunofixation abnormalities was more important in patients affected by malignant hemopathies than in patients affected by other pathologies (70.5% vs 35.8%). A high frequency of monoclonal immunoglobulins was found in patients with lymphoma (53.3%) and oligoclonal immunoglobulins in other hemopathies (48.2%). No significant difference of the frequency of the monoclonal immunoglobulin isotypes was found. In summary, this retrospective study demonstrates a high frequency of immunofixation abnormalities in malignant hemopathies other than multiple myeloma and Waldenström’s macroglobulinemia and different immunofixation characteristics between lymphomas and other hemopathies. |
Keywords : Immunofixation - Hemopathie - Immunoglobulin - Monoclonal gammapathie - Dysglobulinemia. |
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