Author(s) : J. Frey, 22 rue Balay, 42000 Saint-Étienne.
Summary : Epidemiological and immunohistochemical studies focus the interest on the contribution of carbohydrates in the pathophysiology of Alzheimer's disease. Diabetes mellitus increases the risk. In the extracellular (senile) plaques, which contain aggregates of amyloid proteins, and in the neurofibrillary tangles within the cytoplasm of neurons, advanced glycation end products were detected. It is discussed whether it is a cause or an effect of the Alzheimer's disease. The vascular origin of the lesions is also considered.
Figure 1. Réaction
inflammatoire induite par la stimulation des récepteurs aux produits
finaux de glycation (RAGE).
Figure 2. Effets convergents
de la glycation et de la lipoperoxydation sur la formation des plaques séniles
par : réactions chimiques (flèches bleues), signaux cellulaires
(flèches discontinues noirs), effets biologiques (flèches
continues noirs).
Printable version
