Institut Gustave-Roussy, 94805 Villejuif Cedex
- Key words: thyroid carcinoma, oncogen
- Page(s) : 37-43
- Published in: 2005
Papillary thyroid carcinomas are characterized in 70 % of cases by the presence of either a RET/PTC rearrangement, or an activating point mutation of RAS or BRAF genes that induce a constitutive activation of the MAP kinase pathway. Follicular carcinomas are characterized by the presence of a RAS mutation or of a PAX8-PPARγ rearrangement. Inactivating mutations of the p53 gene are found only in anaplastic thyroid carcinomas.