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Bulletin du Cancer

Invovlement of ephrins and their receptors in oncogenesis Volume 87, numéro 7-8, Numéro double 7 - 8, Juillet -Août 2000

  • Author(s): Gilles L’Allemain , Institut de recherches signalisation, biologie du développement et cancer, CNRS UMR 6543, Centre de biochimie, Parc Valrose, 06108 Nice Cedex 2.
  • Key words: ephrin, angiogenesis.
  • Page(s) : 529-30
  • Published in: 2000

Ephrins are membrane-linked ligands with an autocrine and/or immediate paracrine action. Ephrins were previously involved in embryonic neurogenesis, axonal guidance and/or retraction. Here, we will present data of the literature describing their roles in angiogenesis and in tumor progression. The capacity for ephrins to act in opposite directions will be discussed.