- Author(s): Gilles L’Allemain
, Institut de recherches signalisation, biologie du développement et cancer, CNRS UMR 6543, Centre de biochimie, Parc Valrose, 06108 Nice Cedex 2.
- Key words: ephrin, angiogenesis.
- Page(s) : 529-30
- Published in: 2000
Ephrins are membrane-linked ligands with an autocrine and/or immediate paracrine action. Ephrins were previously involved in embryonic neurogenesis, axonal guidance and/or retraction. Here, we will present data of the literature describing their roles in angiogenesis and in tumor progression. The capacity for ephrins to act in opposite directions will be discussed.