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Bulletin du Cancer

Focus on granulocyte colony-stimulating factor induced pulmonary toxicity Volume 99, issue 2, Février 2012

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  • Author(s): Élise Noël-Savina, Renaud Descourt , CHU de Brest, hôpital Morvan, service d’oncologie thoracique, 5, avenue Foch, 29200 Brest, France
  • Key words: granulocyte colony-stimulating factor, ARDS, pneumonia, neutropenia, recovery aplasia, pulmonary toxicity
  • Page(s) : 211-7
  • DOI : 10.1684/bdc.2011.1534
  • Published in: 2012

Granulocyte colony-stimulating factor (G-CSF) are frequently used in oncology and haematology practice. Respiratory disturbance has been reported during administration of G-CSF. G-CSF may induce pulmonary toxicity but this fact remains an open debate because of its frequent association with other drugs. The action of these treatments could explain a part of the pulmonary events but not completely. The specific pulmonary effect of the G-CSF is probably underestimated. Most of these pulmonary events occur in association with other risk factors, mainly when a pneumonia occurs during the neutropenia. However, G-CSF are recommended in febrile neutropenia.