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Bulletin du Cancer

Cell cycle and molecular targets: CDK inhibition Volume 99, numéro 2, Février 2012

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  • Author(s): Philippe Carassou, Laurent Meijer, Sylvestre Le Moulec, Jean Aoun, Leila Bengrine-Lefèvre , HIA Legouest, service de médecine interne, BP 90001, 57077 Metz Cedex 3, France, CNRS, groupe cycle cellulaire, station biologique, BP 74, 29682 Roscoff Cedex, France, HIA Val-de-Grâce, oncologie médicale, 75230 Paris Cedex 05, France, Hôpital Saint-Antoine, oncologie médicale, 75571 Paris Cedex 12, France
  • Key words: cell cycle, cyclin-dependent kinases, roscovitine, indirubin, meriolin, antitumor activity
  • Page(s) : 163-71
  • DOI : 10.1684/bdc.2011.1383
  • Published in: 2012

Protein phosphorylation is a fundamental post-translational modification. It regulates a large number of critical cellular processes (differentiation, division, proliferation, apoptosis). Cell division is a process including a series of phases by which a parent cell divides into two daughter cells. The cells enter these stages then progress within the cell division under an accurate control by many proteins. These proteins are activated by phosphorylation. Cyclin-dependent kinases are responsible for this phosphorylation and therefore represent potential therapeutic targets especially in oncology.