John Libbey Eurotext

Bulletin du Cancer

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Alternative p19 protein: a genuine tumor suppressor gene Volume 85, issue 4, Avril 1998

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The p16 INK4a gene located in the MTS1 (multiple tumor suppressor1) locus encodes two proteins, p16 INK4a and p19 ARF, which are structurally unrelated but functionally similar as both inhibit cell cycle progression. In this review, we report and comment new data obtained from mice knockouted for p19 ARF without interfering with the expression of p16 INK4a. This results in the rapid occurrence of a spectrum of tumors. These data establish that p19 ARF is a genuine tumor suppressor protein and raise the questions of the relationship between the two proteins and their respective importance in malignancies.