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Lipidomics of Alzheimer's disease: a liver peroxisomal dysfunction in the metabolism of omega-3 fatty acids |
Oléagineux, Corps Gras, Lipides. Volume 18, Number 4, 218-23, Juillet - Août 2011: Lipids and Brain II – Actes des Journées Chevreul 2011 (Première partie), PUFA, CHOLESTEROL AND ALZHEIMER DISEASES
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 Free Article
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Author(s) : Giuseppe Astarita, Daniele Piomelli |
Summary : Reduced brain levels of docosahexaenoic acid (DHA), a neurotrophic and neuroprotective fatty acid, might contribute to cognitive and visual decline. A multi-organ lipidomic approach revealed that the levels of free DHA, DHA-containing phospholipids precursors and DHA-metabolites were decreased in various brain regions of subjects with Alzheimer's disease (AD), compared to control subjects. Furthermore, liver DHA content was lower in AD patients than control subjects. Shorter chain omega-3 fatty acids precursors for DHA, were elevated in liver of AD patients, whereas expression of peroxisomal D-bifunctional protein, which catalyzes the conversion of tetracosahexaenoic acid into DHA, was selectively reduced. Lower DHA levels in the liver were associated with cognitive impairment and with higher prevalence of eye-diseases. The evidence presented herein indicate that a deficit in liver biosynthesis of DHA possibly lessens the flux of this neuroprotective fatty acid to brain and eyes, contributing to cognitive and visual impairments. |
Keywords : DHA, omega-3 fatty acids, liver, Alzheimer's disease, cognition, eyes |
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