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Discrepancies in FVII:C levels depending on the thromboplastin: about a case Volume 78, issue 2, Mars-Avril 2020

Authors
1 Service d’hématologie biologique, Centre de biologie et de pathologie Sud, Hospices civils de Lyon, France
2 Service d’hématologie biologique, Centre de biologie et de pathologie Est, Hospices civils de Lyon, France
3 Unité d’hémostase clinique, Hôpital cardiologique Louis Pradel, Hospices civils de Lyon, France
* Correspondance

Factor VII deficiency is the most common of the rare coagulation deficiencies. A hemorrhagic syndrome may occur in patients with FVII deficiency below 20%, although no correlation exist between the plasma FVII activity level (FVII:C) and the bleeding risk. Therefore, the management of surgery in patients with FVII deficiency remains challenging. Laboratory monitoring of FVII:C level may be helpful but should be interpreted with caution, because the dosage of FVII:C level may vary depending on the origin of the thromboplastin used. Herein, we report the case of the management of a woman who had been fortuitously diagnosed during pregnancy with FVII deficiency due to FVII variant Padua, which have induced discrepant results between two different laboratories.

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