JLE

Annales de Biologie Clinique

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Detection of HLA antibodies by Luminex and kidney transplantation decision making: a case report Volume 72, issue 6, Novembre-Décembre 2014

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Authors
1 Unité d’histocompatibilité, Service de transfusion sanguine et d’hémovigilance, Centre hospitalier Ibn Sina, Rabat, Maroc
2 UPR d’immunologie, Faculté de médecine et de pharmacie de Rabat, Université Mohamed V, Maroc

We report the case of a patient planned for living-related donor kidney transplantation. HLA antibodies research, performed by the Luminex method, is positive for all the available sera. Cross match was performed by complement-dependent lymphocytotoxicity technique with three family members. The first donor, her husband, was excluded due to the positivity of the cross-match and the presence of donor-specific anti HLA antibody (DSA). The second one, her daughter, was immediately excluded because the recipient also presented DSA. Despite the negativity of the cross match, the decision to transplant the patient with the third donor, her son, was difficult to take because of the presence of DSA identified by the Luminex method. Consequently, the patient could not be transplanted.