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Annales de Biologie Clinique

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De la nécessité de bien définir les valeurs de référence des hormones thyroïdiennes pour une meilleure interprétation clinique Volume 69, issue 1, Février 2011

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Authors
Laboratoire de biochimie, Centre hospitalier, Meaux, Beckman Coulter France, Villepinte, Service d’endocrinologie, Centre hospitalier, Meaux

Discordances were observed with thyroid reference range from BCF Access 2 analyser. The purpose of this study was to establish specific reference range value for free thyroxine (FT4), free triiodothyronine (FT3) and thyrotropin (TSH) in adult Meaux Hospital population. Samples from 308 adults aged from 18 to 65 years were studied. Patients (no pregnancy and no iodine contrast media used) after informed consent, were exempted of thyroidal, cardiac, renal, multiple-organ-failure illnesses. Thyroid assays, anti-TPO and anti-TG levels were measured on the BCF Access2 immunoassay system. This work exposes difficulties to define range values in order to better use the biomarker in the clinical context.