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Accreditation of the toxicological screening: recommendations of the SFBC-SFTA group Volume 77, issue 2, Mars-Avril 2019

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Authors
1 Laboratoire de pharmacologie-toxicologie, Centre de biologie Sud, Hospices civils de Lyon, Pierre-Bénite, France
2 Laboratoire de toxicologie, CHU de Lille, France
3 Laboratoire de pharmacologie-toxicologie, AP-HP, CHU Raymond Poincaré, Garches, France
4 Laboratoire de médecine légale et toxicologie, Université Grenoble-Alpes, Domaine de La Merci, La Tronche, France
5 Laboratoire de pharmacologie, pharmacogénétique et toxicologie, Université Grenoble-Alpes, Grenoble, France
6 Laboratoire de pharmacologie-toxicologie, CHU de Nantes, France
7 Laboratoire de biochimie, Hôpital d’instruction des armées Percy, Clamart, France
8 Laboratoire de biologie, Centre hospitalier régional Chambéry-Savoie, Chambéry, France
9 Service de pharmacologie médicale, CHU de Clermont-Ferrand, France
10 Laboratoire de biochimie-toxicologie, Centre hospitalier régional Metz-Thionville, Thionville, France
11 Service de pharmacologie, toxicologie et pharmacovigilance, CHU de Limoges, France
12 Laboratoire de pharmacologie-toxicologie, Plateforme de biologie hospitalo-universitaire, CHU Dijon, France
* Tirés à part

Toxicological screening is a specific approach to analytical toxicology that uses analytical tools such as GC-MS, LC-UV (diode array) or LC-MS. Toxicological screening allows the detection and simultaneous identification of a large number of compounds. The results may be based on the use of one or more techniques. As part of the accreditation process for medical biology examinations according to standard NF EN ISO 15189, the group from SFTA and SFBC recommends an approach to accredit toxicological screening. Indeed, the complexity of the accreditation of this analysis comes in particular from the high number of compounds that can be detected. Validation parameters are discussed in the specific context of toxicological screening by considering two distinct approaches: the simple identification of compounds, or the identification and estimation of a range of concentration related to clinical outcomes.

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