John Libbey Eurotext




Adjuvant treatments in breast cancer: interest of completion of axillary dissection in case of micrometastases or isolated tumor cells in sentinel lymph node
Bulletin du Cancer. Volume 99, Number 4, 463-9, Avril 2012, Synthèse
Résumé Texte intégral
Author(s) : Caroline Schmitt, Catherine Bouteille, Christelle Faure, Hervé Mignotte, Olivier Tredan, Thomas Bachelot, Jean-Paul Guastalla, Antoine Arnaud, Isabelle Treilleux, Nicolas Carrabin
Summary : Prognostic signification of micrometastases ou isolated tumor cells (ITC) has not yet been clearly precised. Management of the axilla in case of micrometastases or ITC depends on the local pratices: no surgical completion or axillary lymph node dissection (ALND). Axillary lymph node status is the most important prognostic factor in patients with breast cancer\; morbidity of ALND is now well known whereas its therapeutic benefit has not been demonstrated. This study is based on a retrospective database of 1375 patients who underwent sentinel node (SN) biopsy for breast cancer. In case of micrometastase or ITC in SN with completion axillary dissection, we examined if non-sentinel lymph node status has changed the indications of adjuvant treatments (chimiotherapy or radiotherapy). The results of our study show that non-sentinel lymph node status modify systemic therapy for a very few patients (less than 4% concerning chimiotherapy and less than 15% concerning radiotherapy).
Keywords : breast cancer, sentinel lymph node dissection, micrometastase, isolated tumor cells, completion axillary dissection, adjuvant treatment

Adjuvant treatments in breast cancer: interest of completion of axillary dissection in case of micrometastases or isolated tumor cells in sentinel lymph node