Epileptic seizures and cholinergic urticaria with generalized hypohidrosis or anhidrosis

Pictures

Figure 1 Physiological and histopathological examinations. Exercise-induced sweating test shows that the applied iodine-starch reaction was decreased by sweat on the abdomen (hypohidrotic area; A), but not on the back (anhidrotic area; B). The exercise-induced wheals coincide with sweat orifices at the hypohidrotic areas (C). A Histopathological microphotograph of anhidrotic area displays a lymphocytic infiltrate around the sweat glands (D, hematoxyline and eosin, original magnification × 100). Sections from the skin of the hypohidrotic (E) and anhidrotic skin (F) stained with anti-CHRM3 antibody exhibited decreased staining of CHRM3 in the hypohidrotic (E) but not anhidrotic (F) area compared with healthy control (G).