John Libbey Eurotext




Newer technologies/techniques and tools in the diagnosis of melanoma
European Journal of Dermatology. Volume 18, Number 6, 617-31, Novembre-Décembre 2008, Review article
Free Article
Author(s) : Jitendrakumar K Patel, Sailesh Konda, Oliver A Perez, Sadegh Amini, George Elgart, Brian Berman
Summary : A number of non-invasive approaches have been developed over the years to provide an objective means of evaluating and diagnosing skin melanoma. However, the current gold-standard in melanoma diagnosis is the examination of a skin lesion by the trained eye of a physician followed by histological examination of an invasive excisional biopsy of the skin specimen. Diagnosis of melanoma by simple visual examination is incorrect in almost 1 out of every 3 melanoma diagnoses. Therefore, the diagnosis of early stage in-depth melanoma by non-invasive methods remains an active area of research. Recent advancements in computer and digital technology have provided several sensitive tools to evaluate the different characteristics of a melanoma lesion including its contour, edge, color, size, depth, and/or elevation. These tools include (1) digital imaging systems and computer analysis instruments such as MoleMax™, SIAscope™, SolarScan ^®, MelaFind ^TM\; (2) tape stripping mRNA\; (3) laser-based technology such as Confocal scanning laser microscopy (CSLM), optical coherence tomography (OCT), laser Doppler perfusion imaging (LDPI), (4) Ultrasonography, and (5) other imaging tools such as electrical bio-impedance, MRI and PET scan. The ultimate goal of all investigational instrumentation is the prevention of unnecessary biopsies and a decrease in the prevalence and morbidity associated with malignant melanoma.
Keywords : melanoma, dermoscope, ultrasound, MRI, PET scan, digital image analysis

Newer technologies/techniques and tools in the diagnosis of melanoma