John Libbey Eurotext




Imiquimod in mycosis fungoides
European Journal of Dermatology. Volume 18, Number 2, 148-52, march-april 2008, Therapy
Free Article
Author(s) : M Covadonga Martínez-González, M Magdalena Verea-Hernando, M Teresa Yebra-Pimentel, Jesús Del Pozo, Marta Mazaira, Eduardo Fonseca
Summary : Imiquimod is a topically active imidazoquinoline immunomodulator agent. It works as an indirect antiviral and antitumoral and stimulates the production of INF-α and various other cytokines. We assayed topical imiquimod in treating early stages of mycosis fungoides. We applied imiquimod 5% cream in four patients with multi-treatment resistant plaques of MF (stages IA and IIB). We applied it on one patient in association with systemic INFα-2a. We observed a complete clinical clearance of the lesions in all four patients. In three cases we achieved a complete histopathological clearance and in one case a partial histopathological clearance. The patient treated with imiquimod and systemic INFα-2a showed the most spectacular improvement with a rapid total response. We ascribe this improvement to a synergic effect of imiquimod and systemic INFα-2a treatment. Before the introduction of imiquimod, this patient had been treated for 2 years with systemic INFα-2a alone, without any evidence of clinical response. Imiquimod could be an effective therapy for early-stage disease of CTCL, used alone or in combination with systemic immunomodulatory therapy.
Keywords : cutaneous T-cell lymphomas, mycosis fungoides, early-stage disease, topical treatment, imiquimod

Imiquimod in mycosis fungoides