John Libbey Eurotext




Primary cutaneous aggressive epidermotropic CD8 ⁺ T-cell lymphoma with a CD15 ⁺CD30 ^– phenotype
European Journal of Dermatology. Volume 17, Number 5, 441-2, September-October 2007, Clinical report
Free Article
Author(s) : Naho Yoshizawa, Hiroaki Yagi, Takahiro Horibe, Masahiro Takigawa, Makoto Sugiura
Summary : Primary cutaneous aggressive epidermotropic CD8 ⁺ T-cell lymphoma (CD8 ⁺TCL) is an extremely rare entity with distinct clinicopathological features. While the CD15 antigen is typically associated with classic Hodgkin’s lymphoma, aggressive peripheral T-cell lymphomas, including advanced stage cutaneous T-cell lymphomas, rarely express this molecule. We report a case of primary cutaneous aggressive epidermotropic CD8 ⁺TCL, in which lymphoma cells are CD15 ⁺CD30 ^– with a medium-to-large pleomorphic phenotype. Although the functional characteristics of CD15 expression in the cutaneous lymphomas are not fully understood, the poor prognosis of primary cutaneous aggressive epidermotropic CD8 ⁺TCL might be associated with the presence of this molecule in our case.
Keywords : CD8 ⁺TCL, CD8 ⁺ T-cell lymphoma, CTCL, Cutaneous T-cell lymphoma, EBV, Epstein-Barr virus, MF, Mycosis fungoides, TCR, T-cell receptor

Primary cutaneous aggressive epidermotropic CD8 + T-cell lymphoma with a CD15 +CD30 – phenotype