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Pemphigus vegetans Neumann type with anti-desmoglein and anti-periplakin autoantibodies |
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European Journal of Dermatology. Volume 17, Number 6, 530-3, November-December 2007, Clinical report |
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 Free Article
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Author(s) : Emanuele Cozzani, Konstantina Christana, Alessandro Mastrogiacomo, Paolo Rampini, Massimo Drosera, Massimo Casu, Giovanni Murialdo, Aurora Parodi |
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Summary : Pemphigus vegetans is a rare variant of pemphigus vulgaris characterized by vegetating lesions in the folds and mouth and by the presence of autoantibodies against desmoglein 3. We describe two Caucasian patients with pemphigus vegetans, one of them presented antibodies to desmoglein 3 and 1 and the other one to desmoglein 3. Both patients also had circulating antibodies against a 190 kDa protein co-migrating with periplakin. Anti-periplakin reactivity is usually detected in paraneoplastic pemphigus, while it has never been reported in pemphigus vegetans. Our observation enlarges the spectrum of autoantibodies which may be associated with pemphigus vegetans. However, the pathophysiological significance of anti-periplakin reactivity in this pemphigus variant remains to be determined. |
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Keywords : desmoglein 1, desmoglein 3, periplakin, autoantibodies, pemphigus vegetans |
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Copyright © 2007 John Libbey Eurotext - Tous droits réservés