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Prognostic value of CA125 half-life and early normalization during chemotherapy in advanced ovarian tumors: results of a multicentric French study |
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Bulletin du Cancer. Volume 94, Number 3, 287-95, Mars 2007, Article original |
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 Résumé
Article gratuit
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Author(s) : Jean-Marc Riedinger, Franck Bonnetain, Nicole Eche, Jean-Pierre Basuyau, Jean Wafflart, Gabriel Ricolleau, Hélène Larbre, Isabelle Dalifard, Marie-France Pichon |
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Summary : This multicentric study was performed in 494 patients with advanced epithelial ovarian cancer in order to assess the predictive and prognostic value of CA125 half-life and CA125 time to normalization during induction chemotherapy in these patients. For 494 stage IIC-IV patients, 397 relapsed (80.4 %) and 382 died (77.3 %) from cancer during follow time (median \= 34 months \; range : 3-215 months). In the population of patients with surgical second look (n \= 194), CA125 half-life and normalization before the third cycle were significantly related to pathological complete response by univariate (p <\; 0,0001) and multivariate (p respectively equal to 0,01 and 0.042) studies. CA 125 half-life and time needed for CA125 normalization had an univariate prognostic value for overall survival (OS) (p <\; 0.0001 for both). In Cox models, CA 125 half-life (p <\; 0.0001), residual tumour (p \= 0.001), CA125 normalization before the third cycle (p \= 0.014) and age (p \= 0.032) were independent prognostic factors for OS. Conclusion : Among well-established prognostic factors in ovarian cancers, CA 125 half-life and CA125 time to normalization were independent prognostic factors for both achievement of pathological complete response and survival. |
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Keywords : CA 125, ovarian cancer, half-life, second-look, survival, chemotherapy |
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Copyright © 2007 John Libbey Eurotext - Tous droits réservés