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Severe gastrointestinal involvement in paraneoplastic pemphigus |
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European Journal of Dermatology. Volume 16, Number 4, 420-2, July-August 2006, Clinical report |
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 Free Article
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Author(s) : Hiroshi Miida, Takashi Kazama, Noriyoshi Inomata, Hideaki Takizawa, Mitsuya Iwafuchi, Masaaki Ito, Ayako Komai, Takashi Hashimoto, Kyouko Togashi |
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Summary : Paraneoplastic pemphigus (PNP) is an autoimmune mucocutaneous disease, associated with neoplasia, which has characteristic clinical, histological and immunological features. While respiratory epithelial involvement has been described in several cases, lesions in the colon epithelium have never been reported. We describe a 57-year-old Japanese woman with PNP who had many aphthae-like erosions on the colon epithelium, in addition to typical mucocutaneous PNP lesions. The intestinal erosions had histological features similar to those of PNP and linear deposition of complement, but not IgG, was observed along the colon epithelial basement membrane. |
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Keywords : paraneoplastic pemphigus, colon lesion, colon basement membrane, complement deposition |
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Copyright © 2007 John Libbey Eurotext - Tous droits réservés